Teaching

1. Dynamics of Biological Systems (BIEN 159 - undergraduate)

 

Text: “Basic Transport Phenomena in Biomedical Engineering” by R. L. Fournier

 

 

Covers engineering principles for the analysis of modeling of biological phenomena. Topics include molecular diffusion and transport, membranes, ligand-bioreceptor interactions, enzyme kinetics, and dynamics of metabolic pathways. Examines the application of these principles to the design of bioreactors, bioassays, drug delivery systems, and artificial tissues.

 


2. Biomedical Imaging (BIEN 160 - undergraduate)

 

Text: “The Essential Physics of Medical Imaging,” edited by J. T. Bushberg et al.

 


An introduction to the fundamental physics and engineering principles for medical imaging systems. Covers X-ray, ultrasound, radionuclide, magnetic resonance imaging, positron emission tomography, optical coherent tomography, and other optical methods. Includes image formation and reconstruction, image characteristics, and quality and image processing.

 

 

3. Biomaterials (BIEN 140A - undergraduate)

 

Text: “Biomaterial Science: An introduction to materials in medicine,” edited by B. Ratner et al.

 

 

Introduction to the biomaterials. Properties of materials (bulk, surface, characterization). Types of materials used for biological and medical applications (polymers, silicon based materials, hydrogels, metals, ceramics, glasses, composites). Biomaterial interfaces (surface derivatization and surface-immobilized biomolecules). Interaction of materials with biological systems (cells, tissues, ECM), protein and cell adhesion, mechanical forces on cells and biological macromolecules

 

4. Biophotonics: Optical Microscopy and it Biological Applications (BIEN 251 - graduate)

 

Fundamentals of optical system design and system integration in light microscopy.

a) Design components: light sources, lenses, mirrors, dispersion elements, optical fibers, detectors.

b) Optical system analysis: transfer functions, magnification, resolution, contrast.

c) Molecular, cellular, organ, and organism applications.

 

 

 

5. Special Topics in Biophotonics (BIEN 267 - graduate)

 

Text: “Biomedical Photonics (Handbook)" edited by Tuan Vo-Dinh

 

 

Focuses on advanced science and technology methods that use electromagnetic radiation for medical and biological applications. Covers photonic devices, detection, microscopy and spectroscopy techniques, and diagnostics and mechanistic ideas on photodynamic therapy.

 

6. Bioengineering Experimentation & Analysis (BIEN 268 - graduate)

 

Introduces measurement principles and data acquisition methods related to biomechanics and biochemical and bioelectrical signals from living systems. Addresses the fundamental mechanisms underlying the operation of various sensor types and the modern instruments illustrating noise analysis, filtering, signal processing, and conditioning. Includes experiments aimed at investigating physical responses of cells and tissues to a variety of stimuli.

 

 

Laboratory experiment & project highlights:

 

· Electrocardiogram (ECG) Detection and Analysis with a BIOPAC Student Lab

 

· Surface Plasmon Resonance (SPR) sensing with a modular Spreeta sensing platform: sensing platform setup and calibration using sucrose solutions, immobilization of goat IgG antibody onto carboxylated protein film by amine coupling

 

 

 

7. Directed Research / Technical Research Elective (BIEN 197 - undergraduate)

 

 

Laboratory-based project highlights:

 

 

· Novel Raman detection of water content within the glyceraldehyde-modified collagen hydrogels

 

· Collagen self-assembly kinetics in presence of glycosaminoglycan co-polymers

 

· Fructose cross-linking of collagen protein

 

· Effects of the potential glioblastoma chemotherapy drugs pimozide and risperidone on the formation of actin fibers in the 3D glioblastoma spheroid model

 

· Measurement of Ti:Sapph femtosecond pulses by intensity autocorrelation

 

 

 

8. Special Studies (BIEN 190 - undergraduate)

 

 

Literature-based research project highlights:

 

 

· Comparative investigation of experimental and computational methods used in characterizing the material properties of engineered tissues

 

 

 

9. Contributions to Undergraduate Senior Design (BIEN 175 - undergraduate)

 

 

Design project highlights:


· Thermo-Modulating Microscope Stage Insert – a Peltier-based device for the advanced analytical measurements

 

· Point-of-Care Device Container for transporting engineered living tissues

 

 

 
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